Start with a Downtown address near the connected transit network, a workable Hillcrest or North Park bus connection, or a University-area address genuinely within reach of the Blue Line and daily shopping. These are stronger starting points for reducing driving than choosing a large area by name. Compare actual homes: an inconvenient crossing or long walk through a site can undo the apparent advantage.
A La Jolla coastal address is a different proposition from a unit near UTC or a campus station. A Rancho Bernardo home can use the I-15 Rapid corridor while still needing a separate connection for groceries, leisure and the trip home from the station. A remote job removes one commute, not those other journeys. A home deep in an inland residential area needs a more deliberate paid-ride or agreed-ride budget.
Try a complete week before choosing: food and household shopping with bags, a medical or administrative visit, a social evening, a weekend park or cultural outing and any child collection. Check both directions on the relevant day. For late trips, identify the last usable connection all the way home, rather than the last vehicle leaving one central station.
For airport trips, MTS lists Route 992 between Downtown and the terminals from about 4:30 a.m. to 1 a.m. daily, generally every 15 minutes. The free San Diego Flyer links Old Town and the airport from about 4:45 a.m. to 12:30 a.m., generally every 20–30 minutes. There is no direct Trolley into the terminals, and Old Town does not provide overnight parking. Match the flight and the terminal stop with the current day's service; leave an available alternative if a delay runs beyond it.
Someone without a license can combine usable transit, deliveries, an available taxi or ride-hail and specific help another person has agreed to provide. For a regional outing beyond that workable network, arrange the return as carefully as the outward leg. A rental vehicle is an option only for an eligible driver. Do not assume a car-share account, a friend's availability or a ride late at night until the actual arrangement exists.